Doryphagy: when selective autophagy safeguards centrosome integrity

Abstract

Although centrosome abnormalities are frequent in cancer, the mechanisms responsible for their accumulation are poorly understood. Here we comment on our recent publication identifying a new type of selective autophagy, named doryphagy, which preserves centrosome organization through targeting Centriolar Satellites (CS). Thus, doryphagy prevents inaccurate mitosis and genomic instability.

Keywords

• autophagy
• centriolar satellites
• centrosome
• doryphagy
• gabarap
• gabarapl2
• mitosis
• pcm1
• selective autophagy