A cytoskeleton regulator AVIL drives tumorigenesis in glioblastoma

Zhongqiu Xie; Pawel Ł. Janczyk; Ying Zhang; Aiqun Liu; Xinrui Shi; Sandeep Singh; Loryn Facemire; Kristopher Kubow; Zi Li; Yuemeng Jia; Dorothy Schafer; James W. Mandell; Roger Abounader; Hui Li

doi:10.1038/s41467-020-17279-1

Nature Communications (Jul 2020)

A cytoskeleton regulator AVIL drives tumorigenesis in glioblastoma

Zhongqiu Xie,
Pawel Ł. Janczyk,
Ying Zhang,
Aiqun Liu,
Xinrui Shi,
Sandeep Singh,
Loryn Facemire,
Kristopher Kubow,
Zi Li,
Yuemeng Jia,
Dorothy Schafer,
James W. Mandell,
Roger Abounader,
Hui Li

Affiliations

Zhongqiu Xie: Department of Pathology, School of Medicine, University of Virginia
Pawel Ł. Janczyk: Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia
Ying Zhang: Department of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia
Aiqun Liu: Tumor Hospital, Guangxi Medical University
Xinrui Shi: Department of Pathology, School of Medicine, University of Virginia
Sandeep Singh: Department of Pathology, School of Medicine, University of Virginia
Loryn Facemire: Department of Pathology, School of Medicine, University of Virginia
Kristopher Kubow: Department of Biology, James Madison University
Zi Li: Department of Orthopedics, The Second Xiangya Hospital, Central South University
Yuemeng Jia: Department of Pathology, School of Medicine, University of Virginia
Dorothy Schafer: Department of Biology, University of Virginia
James W. Mandell: Department of Pathology, School of Medicine, University of Virginia
Roger Abounader: Department of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia
Hui Li: Department of Pathology, School of Medicine, University of Virginia

DOI: https://doi.org/10.1038/s41467-020-17279-1
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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Genes that modulate the cytoskeleton have been associated with increased cell proliferation and migration. Here, the authors show that AVIL, an actin regulatory protein, is overexpressed in glioblastomas and mediates oncogenic effects through regulation of FOXM1 stability and LIN28B expression.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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