Frontiers in Pharmacology (Sep 2022)
Metabolomics study of treatment response to conbercept of patients with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy
- Yinchen Shen,
- Yinchen Shen,
- Yinchen Shen,
- Yinchen Shen,
- Yinchen Shen,
- Hanying Wang,
- Hanying Wang,
- Hanying Wang,
- Hanying Wang,
- Hanying Wang,
- Xiaoyin Xu,
- Xiaoyin Xu,
- Xiaoyin Xu,
- Xiaoyin Xu,
- Xiaoyin Xu,
- Chong Chen,
- Chong Chen,
- Chong Chen,
- Chong Chen,
- Chong Chen,
- Shaopin Zhu,
- Shaopin Zhu,
- Shaopin Zhu,
- Shaopin Zhu,
- Shaopin Zhu,
- Lu Cheng,
- Lu Cheng,
- Lu Cheng,
- Lu Cheng,
- Lu Cheng,
- Junwei Fang,
- Junwei Fang,
- Junwei Fang,
- Junwei Fang,
- Junwei Fang,
- Kun Liu,
- Kun Liu,
- Kun Liu,
- Kun Liu,
- Kun Liu,
- Xun Xu,
- Xun Xu,
- Xun Xu,
- Xun Xu,
- Xun Xu
Affiliations
- Yinchen Shen
- Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
- Yinchen Shen
- National Clinical Research Center for Eye Diseases, Shanghai, China
- Yinchen Shen
- Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China
- Yinchen Shen
- Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China
- Yinchen Shen
- Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China
- Hanying Wang
- Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
- Hanying Wang
- National Clinical Research Center for Eye Diseases, Shanghai, China
- Hanying Wang
- Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China
- Hanying Wang
- Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China
- Hanying Wang
- Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China
- Xiaoyin Xu
- Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
- Xiaoyin Xu
- National Clinical Research Center for Eye Diseases, Shanghai, China
- Xiaoyin Xu
- Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China
- Xiaoyin Xu
- Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China
- Xiaoyin Xu
- Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China
- Chong Chen
- Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
- Chong Chen
- National Clinical Research Center for Eye Diseases, Shanghai, China
- Chong Chen
- Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China
- Chong Chen
- Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China
- Chong Chen
- Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China
- Shaopin Zhu
- Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
- Shaopin Zhu
- National Clinical Research Center for Eye Diseases, Shanghai, China
- Shaopin Zhu
- Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China
- Shaopin Zhu
- Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China
- Shaopin Zhu
- Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China
- Lu Cheng
- Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
- Lu Cheng
- National Clinical Research Center for Eye Diseases, Shanghai, China
- Lu Cheng
- Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China
- Lu Cheng
- Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China
- Lu Cheng
- Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China
- Junwei Fang
- Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
- Junwei Fang
- National Clinical Research Center for Eye Diseases, Shanghai, China
- Junwei Fang
- Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China
- Junwei Fang
- Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China
- Junwei Fang
- Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China
- Kun Liu
- Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
- Kun Liu
- National Clinical Research Center for Eye Diseases, Shanghai, China
- Kun Liu
- Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China
- Kun Liu
- Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China
- Kun Liu
- Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China
- Xun Xu
- Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
- Xun Xu
- National Clinical Research Center for Eye Diseases, Shanghai, China
- Xun Xu
- Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China
- Xun Xu
- Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China
- Xun Xu
- Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China
- DOI
- https://doi.org/10.3389/fphar.2022.991879
- Journal volume & issue
-
Vol. 13
Abstract
Graphical AbstractAMD, age-related macular degeneration; PCV, polypoidal choroidal vasculopathy; PLS-DA, partial least squares discriminant analysis; LPC, lysophosphatidylcholine; PC, phosphocholine; ROC, operating characteristic curve; AUC, area under the receiver operating characteristic curve; vWF, von Willebrand Factor. Note: The protein structure of vWF is downloaded from PDB (https://www.rcsb.org/).
Keywords
- anti-vegf
- neovascular age-related macular degeneration
- polypoidal choroidal vasculopathy
- metabolomics
- treatment response
