Effects of Short-, Medium-, and Long-Term Treatment Using Photobiomodulation Therapy Combined with Static Magnetic Field in Aging Rats
Kadma Karênina Damasceno Soares Monteiro,
Shaiane Silva Tomazoni,
Gianna Móes Albuquerque Pontes,
Adeilson Matias Teixeira,
Fernanda Aparecida de Araújo Agra,
Carolina Barros Alvim,
Sâmela Lopes Medeiros Brigato,
Rodrigo Labat Marcos,
Humberto Dellê,
Andrey Jorge Serra,
Ernesto Cesar Pinto Leal-Junior
Affiliations
Kadma Karênina Damasceno Soares Monteiro
Laboratory of Phototherapy and Innovative Technologies in Health (LaPIT), Post-Graduate Program in Rehabilitation Sciences, Nove de Julho University, São Paulo 01504-001, Brazil
Shaiane Silva Tomazoni
ELJ Consultancy, São Paulo 04076-000, Brazil
Gianna Móes Albuquerque Pontes
Laboratory of Phototherapy and Innovative Technologies in Health (LaPIT), Post-Graduate Program in Rehabilitation Sciences, Nove de Julho University, São Paulo 01504-001, Brazil
Adeilson Matias Teixeira
Laboratory of Phototherapy and Innovative Technologies in Health (LaPIT), Post-Graduate Program in Rehabilitation Sciences, Nove de Julho University, São Paulo 01504-001, Brazil
Fernanda Aparecida de Araújo Agra
Laboratory of Phototherapy and Innovative Technologies in Health (LaPIT), Post-Graduate Program in Rehabilitation Sciences, Nove de Julho University, São Paulo 01504-001, Brazil
Carolina Barros Alvim
Laboratory of Phototherapy and Innovative Technologies in Health (LaPIT), Post-Graduate Program in Rehabilitation Sciences, Nove de Julho University, São Paulo 01504-001, Brazil
Sâmela Lopes Medeiros Brigato
Laboratory of Phototherapy and Innovative Technologies in Health (LaPIT), Post-Graduate Program in Rehabilitation Sciences, Nove de Julho University, São Paulo 01504-001, Brazil
Rodrigo Labat Marcos
Post-Graduate Program in Biophotonics, Nove de Julho University, São Paulo 01504-001, Brazil
Humberto Dellê
Post-Graduate Program in Medicine, Nove de Julho University, São Paulo 01504-001, Brazil
Andrey Jorge Serra
Post-Graduate Program in Cardiology, Federal University of São Paulo, São Paulo 04024-002, Brazil
Ernesto Cesar Pinto Leal-Junior
Laboratory of Phototherapy and Innovative Technologies in Health (LaPIT), Post-Graduate Program in Rehabilitation Sciences, Nove de Julho University, São Paulo 01504-001, Brazil
(1) Background: We investigated the detrimental and protective effects of short-, medium, and long-term treatment with different doses of photobiomodulation therapy combined with static magnetic field (PBMT-sMF) during the aging process. (2) Methods: Rats were treated for 15, 30, and 60 weeks with 1, 3, 10, and 30 J of PBMT-sMF or a placebo control. In addition, eight young rats were not subjected to any procedure or treatment and were euthanized at six weeks old. Skin, muscle, bone, kidney, liver, and blood samples were analyzed. (3) Results: No differences between the groups in the morphology of the skin, muscle, and bone was observed. Glutamic pyruvic transaminase levels were increased in the placebo group after 30 and 60 weeks. Glutamic oxaloacetic transaminase levels were also increased in the placebo group after 30 weeks. An increase in creatinine in the PBMT-sMF 3, 10, and 30 J groups compared with that in the young control group was observed. No significant difference in urea levels between the groups was noted. Vascular endothelial growth factor increased in the PBMT-sMF 10 and 30 J groups after 15 weeks of treatment and in the PBMT-sMF 3 J after 60 weeks. Finally, vascular endothelial growth factor decreased in the PBMT-sMF 30 J group after 30 weeks of treatment. (4) Conclusions: PBMT-sMF did not have detrimental effects on the skin, muscle, bone, kidney, or liver after short-, medium-, and long-term treatments in aging rats. In addition, PBMT-sMF may have protective effects on the muscle tissue in aging rats after short- and long-term treatment.
