P6 Effect of platelet-rich xenogenic gel on induced skin ulcer healing in a rat model with type 2 diabetes

Abstract

Introduction: skin ulcers can generate serious complications in people with diabetes, which can lead to partial or total amputation of the compromised limb. Platelet-rich gel is being used frequently to promote the healing of a skin ulcer. However, the clinical outcomes in healing are often variable because the factors that influence this procedure are not yet fully understood. Objective: to evaluate the effect of the platelet-rich xenogenic gel on the healing of an induced skin ulcer in a model in rats with type 2 diabetes (T2D). Materials and methods: 12 Sprague dawley rats were used and divided into 3 groups of 4 rats with an induced 15mm skin ulcer each. Group 1 (with T2D): platelet-rich xenogenic gel was applied. Group 2 (rats with T2D) and group 3 (rats without T2D) applied saline and a dressing. The wound surface was measured on days 0, 20, 29 and 33 using a digital micrometer and photographs.

Keywords

• gel xenogénico
• úlcera cutánea
• diabetes tipo 2