Solubility measurement of poorly soluble drugs in fasted state simulated intestinal fluid

Abstract

Adequate drug solubility in the gastrointestinal tract is essential for systemic therapy of orally administered medications. To carry out research on the solubility of poorly soluble drugs in vitro, simulated intestinal fluid (SIF) is used in place of human intestinal fluid (HIF). However, typical SIF reflects average compositions of HIF rather than the full range of compositions previously reported. This study examines a new suite of SIF media (based on variability observed in HIF) to explore the range of solubility of four poorly soluble drugs(Naproxen, Indomethacin, Phenytoin and Tadalafil) in the fasted state.

Keywords

• solubility
• fasted state
• absorption
• intestinal fluid