Differentiation of Prions from L-type BSE versus Sporadic Creutzfeldt-Jakob Disease

Abstract

We compared transmission characteristics for prions from L-type bovine spongiform encephalopathy and MM2-cortical sporadic Creutzfeldt-Jakob disease in the Syrian golden hamster and an ovine prion protein–transgenic mouse line and isolated distinct prion strains. Our findings suggest the absence of a causal relationship between these diseases, but further investigation is warranted.

Keywords

• prions
• Creutzfeldt-Jakob disease
• sporadic
• sCJD
• bovine spongiform encephalopathy
• BSE