2,3-Bis((<i>E</i>)-4-hydroxybenzylidene)-<i>N</i>1,<i>N</i>4-bis(4-methylbenzyl)succinamide

Abstract

Lignans and neolignans are dimeric natural products with an extraordinary variety of structures and biological properties. Diphenylbutadienes are a subclass of lignans rarely found in nature with cannabisin G being the most representative example. This lignan, found in Cannabis sativa seed, has shown anti-inflammatory and antioxidant activity among other biological properties. Different methodologies have been reported for the synthesis of cannabis G to be employed in new biological studies. We report herein a green and concise procedure based on the use of Trametes versicolor laccase for the synthesis of a new diphenylbutadiene. The developed procedure may be employed for the synthesis of cannabisin G and other analogues.

Keywords

• lignans
• biocatalyst
• laccase
• synthesis