Cell Reports
(Feb 2015)
Dependence of Brown Adipose Tissue Function on CD36-Mediated Coenzyme Q Uptake
Courtney M. Anderson,
Melissa Kazantzis,
Jinshan Wang,
Subramaniam Venkatraman,
Renata L.S. Goncalves,
Casey L. Quinlan,
Ryan Ng,
Martin Jastroch,
Daniel I. Benjamin,
Biao Nie,
Candice Herber,
An-Angela Ngoc Van,
Michael J. Park,
Dawee Yun,
Karen Chan,
Angela Yu,
Peter Vuong,
Maria Febbraio,
Daniel K. Nomura,
Joseph L. Napoli,
Martin D. Brand,
Andreas Stahl
Affiliations
Courtney M. Anderson
Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA
Melissa Kazantzis
Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA
Jinshan Wang
Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA
Subramaniam Venkatraman
Department of Electrical Engineering and Computer Sciences, University of California Berkeley, Berkeley, CA 94720, USA
Renata L.S. Goncalves
The Buck Institute for Research on Aging, Novato, CA 94945, USA
Casey L. Quinlan
The Buck Institute for Research on Aging, Novato, CA 94945, USA
Ryan Ng
The Buck Institute for Research on Aging, Novato, CA 94945, USA
Martin Jastroch
The Buck Institute for Research on Aging, Novato, CA 94945, USA
Daniel I. Benjamin
Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA
Biao Nie
Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA
Candice Herber
Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA
An-Angela Ngoc Van
Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA
Michael J. Park
Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA
Dawee Yun
Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA
Karen Chan
Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA
Angela Yu
Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA
Peter Vuong
Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA
Maria Febbraio
Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2R3, Canada
Daniel K. Nomura
Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA
Joseph L. Napoli
Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA
Martin D. Brand
The Buck Institute for Research on Aging, Novato, CA 94945, USA
Andreas Stahl
Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720, USA
DOI
https://doi.org/10.1016/j.celrep.2014.12.048
Journal volume & issue
Vol. 10,
no. 4
Abstract
Read online
Brown adipose tissue (BAT) possesses the inherent ability to dissipate metabolic energy as heat through uncoupled mitochondrial respiration. An essential component of the mitochondrial electron transport chain is coenzyme Q (CoQ). While cells synthesize CoQ mostly endogenously, exogenous supplementation with CoQ has been successful as a therapy for patients with CoQ deficiency. However, which tissues depend on exogenous CoQ uptake as well as the mechanism by which CoQ is taken up by cells and the role of this process in BAT function are not well understood. Here, we report that the scavenger receptor CD36 drives the uptake of CoQ by BAT and is required for normal BAT function. BAT from mice lacking CD36 displays CoQ deficiency, impaired CoQ uptake, hypertrophy, altered lipid metabolism, mitochondrial dysfunction, and defective nonshivering thermogenesis. Together, these data reveal an important new role for the systemic transport of CoQ to BAT and its function in thermogenesis.
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