Improvement in progressive multifocal leukoencephalopathy after pembrolizumab‐induced immune reconstruction inflammatory syndrome in a patient with follicular lymphoma
Inès Dufour,
Thierry Duprez,
Marie Wertz,
Pascale Saussoy,
Nathalie Ackermans,
Souraya El Sankari,
Vincent van Pesch,
Eric Van Den Neste
Affiliations
Inès Dufour
Department of Hematology Université catholique de Louvain, Cliniques universitaires Saint‐Luc Brussels Belgium
Thierry Duprez
Department of Radiology and Medical Imaging Université catholique de Louvain, Cliniques universitaires Saint‐Luc Brussels Belgium
Marie Wertz
Department of Neurology Clinique Notre‐Dame de Grâce Gosselies Belgium
Abstract Progressive multifocal leukoencephalopathy (PML) may develop in follicular lymphoma patients treated with bendamustine‐rituximab. In this report, treatment with pembrolizumab successfully inhibited the clinical progression of PML by promoting radiologically demonstrated immune restoration inflammatory syndrome (IRIS), allowing complete clearance of the virus. These findings may further support the use of pembrolizumab in PML with special consideration for the potential occurrence of IRIS.
