Ambient particulate matter associates with asthma in high altitude region: A population-based study

ZhenZhen Xing, MD; Ting Yang, MD, PhD; Su Shi, MD; Xia Meng, MD; Renjie Chen, MD, PhD; Huanyu Long, MD; Yanlu Hu, MD; Di Chai, MD; WeiMing Liu, MD; YaQi Tong, MD; YuXia Wang, MD; YaLi Ma, MD; MingMing Pan, MD; Jia Cui, MD; TieYing Sun, MD, PhD; YanFei Guo, MD, PhD

World Allergy Organization Journal (May 2023)

Ambient particulate matter associates with asthma in high altitude region: A population-based study

ZhenZhen Xing, MD,
Ting Yang, MD, PhD,
Su Shi, MD,
Xia Meng, MD,
Renjie Chen, MD, PhD,
Huanyu Long, MD,
Yanlu Hu, MD,
Di Chai, MD,
WeiMing Liu, MD,
YaQi Tong, MD,
YuXia Wang, MD,
YaLi Ma, MD,
MingMing Pan, MD,
Jia Cui, MD,
TieYing Sun, MD, PhD,
YanFei Guo, MD, PhD

Affiliations

ZhenZhen Xing, MD: Peking University Fifth School of Clinical Medicine, Beijing, China; Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China
Ting Yang, MD, PhD: Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, China; National Center for Respiratory Medicine & National Clinical Research Center for Respiratory Diseases, China; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, China; Department of Respiratory Medicine, Capital Medical University, Beijing, China
Su Shi, MD: School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China
Xia Meng, MD: School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China
Renjie Chen, MD, PhD: School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China
Huanyu Long, MD: Peking University Fifth School of Clinical Medicine, Beijing, China; Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China
Yanlu Hu, MD: Peking University Fifth School of Clinical Medicine, Beijing, China; Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China
Di Chai, MD: Peking University Fifth School of Clinical Medicine, Beijing, China; Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China
WeiMing Liu, MD: Department of Intensive Care Medicine, Beijing Boai Hospital, Rehabilitation Research Center, Beijing, China
YaQi Tong, MD: Peking University Fifth School of Clinical Medicine, Beijing, China; Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China
YuXia Wang, MD: Peking University Fifth School of Clinical Medicine, Beijing, China; Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China
YaLi Ma, MD: Peking University Fifth School of Clinical Medicine, Beijing, China; Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China
MingMing Pan, MD: Peking University Fifth School of Clinical Medicine, Beijing, China; Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China
Jia Cui, MD: Peking University Fifth School of Clinical Medicine, Beijing, China; Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China
TieYing Sun, MD, PhD: Peking University Fifth School of Clinical Medicine, Beijing, China; Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China; Corresponding author. No.1 DaHua Road, Dong Dan, Beijing 100730, China.
YanFei Guo, MD, PhD: Peking University Fifth School of Clinical Medicine, Beijing, China; Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China; Corresponding author. No.1 DaHua Road, Dong Dan, Beijing 100730, China.

Journal volume & issue: Vol. 16, no. 5
p. 100774

Abstract

Read online

Background: Exposure to particulate matter (PM) has been a major public health threat, but the potentially differential effects on asthma of PM remain largely unknown in high altitude settings. We evaluated the effects of ambient PM on asthma in high altitude settings. Methods: The study recruited a representative sample from high altitude settings using a multistage stratified sampling procedure. Asthma was defined by a self-reported history of diagnosis by a physician or by wheezing symptoms in the preceding 12 months. The annual mean PM2.5 and PM10 concentrations were calculated for each grid cell at 1-km spatial resolution based on the geographical coordinates. Results: We analyzed data for participants (mean age 39.1 years, 51.4% female) and 183 (3.7%, 95% confidence interval (CI): 3.2–4.2) of the participants had asthma. Prevalence was higher in women (4.3%, 95% CI 3.5–5.1) than in men (3.1%, 2.4–3.8) and increasing with higher concentration of PM exposures. For an interquartile range (IQR) difference (8.77 μg/m3) in PM2.5 exposure, the adjusted odds ratio (OR) was 1.64 (95% CI 1.46–1.83, P < 0.001) for risk of asthma. For PM10, there was evidence for an association with risk of asthma (OR 2.34, 95% CI: 1.75–3.15, P < 0.001 per IQR of 43.26 μg/m3). Further analyses showed that household mold or damp exposure may aggravate PM exposure associated risks of asthma. Conclusions: This study identified that PM exposure could be a dominate environmental risk factor for asthma but largely unconsidered in the high-altitude areas. The association between PM exposure and asthma should be of interest for planners of national policies and encourage programs for prevention of asthma in residents living at high altitudes.

Published in World Allergy Organization Journal

ISSN: 1939-4551 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: https://www.sciencedirect.com/journal/world-allergy-organization-journal

About the journal

Abstract

Keywords