The SIRT7-nucleolus connection in cancer: ARF enters the fray

Shahriar Tarighi; Poonam Kumari; Alejandro Vaquero; Thomas Braun; Alessandro Ianni

doi:10.1080/23723556.2024.2381287

Molecular & Cellular Oncology (Dec 2024)

The SIRT7-nucleolus connection in cancer: ARF enters the fray

Shahriar Tarighi,
Poonam Kumari,
Alejandro Vaquero,
Thomas Braun,
Alessandro Ianni

Affiliations

Shahriar Tarighi: Department of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany
Poonam Kumari: Department of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany
Alejandro Vaquero: Chromatin Biology Laboratory, Josep Carreras Leukaemia Research Institute (IJC), Barcelona, Spain
Thomas Braun: Department of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany
Alessandro Ianni: Department of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany

DOI: https://doi.org/10.1080/23723556.2024.2381287
Journal volume & issue: Vol. 11, no. 1

Abstract

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The nucleolar enzyme sirtuin 7 (SIRT7) promotes cancer progression in certain malignancies, likely in part by controlling ribosome biosynthesis. Recently, we discovered that SIRT7 destabilizes the cyclin dependent kinase inhibitor 2A (CDKN2A, known as ARF) within the nucleolus, aiding cancer progression. We propose that targeting nucleolar SIRT7 offers promise for new anti-cancer therapies.

Published in Molecular & Cellular Oncology

ISSN: 2372-3556 (Online)
Publisher: Taylor & Francis Group
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.tandfonline.com/journals/kmco20

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