Potential pitfalls in diagnosis of immunotherapy-induced hypothalamic– pituitary–adrenal axis suppression

Abstract

We thank Bi and colleagues for their recent case report ‘Potential pitfalls in diagnosis of immunotherapy-induced hypothalamic–pituitary–adrenal axis abnormalities: a clinical case’ (Bi et al. 2022). It provides important lessons on the investigation and management of immunotherapy-related hypophysitis, which is an evolving area within endocrinology and oncology. As part of our work, in a hospital whose oncology service is the Irish national referral centre for several malignancies, we manage ever-increasing numbers of immunotherapy-related hypophysitis and would like to share some further observations.