Analysis of HPV infection in nasal inverted papilloma

Abstract

Objective To analyze the infection of human papilloma virus （HPV） in nasal inverted papilloma （NIP） through experiments, aiming to provide experimental and theoretical basis for further research on the incidence, recurrence and malignant transformation mechanism of HPV-mediated NIP. Methods The infection rates and expression levels of HPV subtypes in the experimental group （NIP group,n = 48） and control group （normal nasal mucosa,n = 20） were detected by nucleic acid molecular rapid diversion hybrid gene chip typing technique （HybriMax）. Results The total positive rate of HPV in the tissue samples of the NIP group was 64.58% （31/48）. The HPV test results of normal nasal mucosa specimens in the control group were all negative, and the difference between two groups was statistically significant （χ2=32.178, P < 0.01）. Forty-nine strains of HPV virus were detected in 31 HPV positive specimens. A total of 12 subtypes were classified including 4.08%（2/49）of HPV6, 32.65%（16/49）of HPV11, 12.24% （6/49）of HPV16,4.08%（2/49）of HPV18, 4.08%（2/49）of HPV33, 2.04%（1/49）of HPV39, 10.20%（5/49）of HPV44, 8.16%（4/49）of HPV52, 2.04%（1/49）of HPV53, 2.04%（1/49）of HPV56, 16.30%（8/49）of HPV58, and 2.04%（1/49）of HPV68. Conclusion HPV infection is closely associated with the incidence of NIP, and the occurrence and development of NIP in China may be correlated with HPV11, 16, 44 and 58 subtypes.

Keywords

• |human papilloma virus|nasal inverted papilloma|subtype|infection rate|recurrence