Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy

Andrey M. Mazarati; Don Shin; Young Se Kwon; Anatol Bragin; Eduardo Pineda; Delia Tio; Anna N. Taylor; Raman Sankar

Neurobiology of Disease (Jun 2009)

Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy

Andrey M. Mazarati,
Don Shin,
Young Se Kwon,
Anatol Bragin,
Eduardo Pineda,
Delia Tio,
Anna N. Taylor,
Raman Sankar

Affiliations

Andrey M. Mazarati: Department of Pediatrics, Neurology Division, David Geffen School of Medicine at the University of California Los Angeles, BOX 951752, 22-474 MDCC, Los Angeles, CA 90095-1752, USA; Corresponding author. Fax: +1 310 825 5834.
Don Shin: Department of Pediatrics, Neurology Division, David Geffen School of Medicine at the University of California Los Angeles, BOX 951752, 22-474 MDCC, Los Angeles, CA 90095-1752, USA
Young Se Kwon: Department of Pediatrics, Neurology Division, David Geffen School of Medicine at the University of California Los Angeles, BOX 951752, 22-474 MDCC, Los Angeles, CA 90095-1752, USA; Department of Pediatrics, College of Medicine, Inha University, Incheon, Republic of Korea
Anatol Bragin: Department of Neurology, David Geffen School of Medicine at the University of California Los Angeles, USA
Eduardo Pineda: Department of Pediatrics, Neurology Division, David Geffen School of Medicine at the University of California Los Angeles, BOX 951752, 22-474 MDCC, Los Angeles, CA 90095-1752, USA
Delia Tio: Department of Neurobiology, David Geffen School of Medicine at the University of California Los Angeles, USA
Anna N. Taylor: Department of Neurobiology, David Geffen School of Medicine at the University of California Los Angeles, USA
Raman Sankar: Department of Pediatrics, Neurology Division, David Geffen School of Medicine at the University of California Los Angeles, BOX 951752, 22-474 MDCC, Los Angeles, CA 90095-1752, USA; Department of Neurology, David Geffen School of Medicine at the University of California Los Angeles, USA

Journal volume & issue: Vol. 34, no. 3
pp. 457 – 461

Abstract

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Depression is frequently reported in epilepsy patients; however, mechanisms of co-morbidity between epilepsy and depression are poorly understood. An important mechanism of depression is disinhibition within the hypothalamo–pituitary–adrenocortical (HPA) axis. We examined the functional state of the HPA axis in a rat model of co-morbidity between temporal lobe epilepsy and depression. Epilepsy was accompanied by the interictal elevation of plasma corticosterone, and by the positively combined dexamethasone/corticotropin releasing hormone test. The extent of the HPA hyperactivity was independent of recurrent seizures, but positively correlated with the severity of depressive behavior. We suggest that the observed hyperactivity of the HPA axis may underlie co-morbidity between epilepsy and depression.

Published in Neurobiology of Disease

ISSN: 0969-9961 (Print); 1095-953X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neurobiology-of-disease

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Abstract

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