International Journal of General Medicine (Apr 2023)

Younger Than 55 Years Old and BRAF V600E Mutation are Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinomas ≤1.0 cm but Not in >1.0 cm

  • Lai Y,
  • Gu Y,
  • Yu M,
  • Deng J

Journal volume & issue
Vol. Volume 16
pp. 1403 – 1414

Abstract

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Yeqian Lai,1,2 Yihua Gu,1,2 Ming Yu,1,2 Jiaqin Deng1,2 1Department of Thyroid Surgery, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of China; 2Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of ChinaCorrespondence: Yeqian Lai, Department of Thyroid Surgery, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, 63 Huangtang Road, Meijiang District, Meizhou, People’s Republic of China, Email [email protected]: Studies on the relationship between BRAF V600E mutation and the clinicopathologic features of papillary thyroid carcinoma (PTC), risk of lymph node metastasis in papillary thyroid microcarcinoma (PTMC) have shown inconsistent results.Methods: In this retrospective analysis, clinicopathological data of the patients were collected, and molecular testing was done for BRAF V600E mutation. PTC patients are divided into PTC≤ 1.0cm (PTMC) and PTC> 1.0cm, and the relationship between BRAF V600E mutation and clinicopathologic features was analyzed respectively.Results: Of the 520 PTC patients, 432 (83.1%) were female and 416 (80.0%) were 1.0cm. BRAF V600E mutation was significantly associated with bilateral cancer (23.0% vs 4.9%, P=0.005) and lymph node metastasis (61.7% vs 39.0%, P=0.009) in PTMC patients, while BRAF V600E mutation was significantly associated with bilateral cancer (24.9% vs 12.3%, P=0.048) in PTC> 1.0cm patients. Logistic regression analysis showed that, after adjusting for gender, Hashimoto’s thyroiditis and calcification, we found that younger age ( 1.0cm.Conclusion: Younger age (< 55 years old) and BRAF V600E mutation was independent risk factor for lymph node metastasis in PTMC.Keywords: papillary thyroid carcinoma, papillary thyroid microcarcinoma, BRAF, lymph node metastasis

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