Nature Communications (Nov 2017)
A transcribed enhancer dictates mesendoderm specification in pluripotency
- Michael Alexanian,
- Daniel Maric,
- Stephen P. Jenkinson,
- Marco Mina,
- Clayton E. Friedman,
- Ching-Chia Ting,
- Rudi Micheletti,
- Isabelle Plaisance,
- Mohamed Nemir,
- Damien Maison,
- Jasmin Kernen,
- Iole Pezzuto,
- Dominic Villeneuve,
- Frédéric Burdet,
- Mark Ibberson,
- Stephen L. Leib,
- Nathan J. Palpant,
- Nouria Hernandez,
- Samir Ounzain,
- Thierry Pedrazzini
Affiliations
- Michael Alexanian
- Experimental Cardiology Unit, Department of Cardiovascular Medicine, University of Lausanne Medical School
- Daniel Maric
- Experimental Cardiology Unit, Department of Cardiovascular Medicine, University of Lausanne Medical School
- Stephen P. Jenkinson
- Neuroinfectiology Laboratory, Institute for Infectious Diseases, University of Bern
- Marco Mina
- Department of Computational Biology, University of Lausanne
- Clayton E. Friedman
- The Institute for Molecular Bioscience, University of Queensland
- Ching-Chia Ting
- Experimental Cardiology Unit, Department of Cardiovascular Medicine, University of Lausanne Medical School
- Rudi Micheletti
- Experimental Cardiology Unit, Department of Cardiovascular Medicine, University of Lausanne Medical School
- Isabelle Plaisance
- Experimental Cardiology Unit, Department of Cardiovascular Medicine, University of Lausanne Medical School
- Mohamed Nemir
- Experimental Cardiology Unit, Department of Cardiovascular Medicine, University of Lausanne Medical School
- Damien Maison
- Experimental Cardiology Unit, Department of Cardiovascular Medicine, University of Lausanne Medical School
- Jasmin Kernen
- Neuroinfectiology Laboratory, Institute for Infectious Diseases, University of Bern
- Iole Pezzuto
- Experimental Cardiology Unit, Department of Cardiovascular Medicine, University of Lausanne Medical School
- Dominic Villeneuve
- Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne
- Frédéric Burdet
- Swiss Institute of Bioinformatics
- Mark Ibberson
- Swiss Institute of Bioinformatics
- Stephen L. Leib
- Neuroinfectiology Laboratory, Institute for Infectious Diseases, University of Bern
- Nathan J. Palpant
- The Institute for Molecular Bioscience, University of Queensland
- Nouria Hernandez
- Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne
- Samir Ounzain
- Experimental Cardiology Unit, Department of Cardiovascular Medicine, University of Lausanne Medical School
- Thierry Pedrazzini
- Experimental Cardiology Unit, Department of Cardiovascular Medicine, University of Lausanne Medical School
- DOI
- https://doi.org/10.1038/s41467-017-01804-w
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 19
Abstract
Long noncoding RNAs (lncRNAs) are key regulators of lineage specification during development. Here, the authors investigate remodeling of enhancers and regulation of the lncRNA transcriptome during mesendoderm specification, and identify a pluripotent stage-specific transcribed enhancer controlling adoption of the mesendodermal cell fate.
