Nature Communications (Sep 2016)
MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C
- Khaled Thabet,
- Anastasia Asimakopoulos,
- Maryam Shojaei,
- Manuel Romero-Gomez,
- Alessandra Mangia,
- William L. Irving,
- Thomas Berg,
- Gregory J. Dore,
- Henning Grønbæk,
- David Sheridan,
- Maria Lorena Abate,
- Elisabetta Bugianesi,
- Martin Weltman,
- Lindsay Mollison,
- Wendy Cheng,
- Stephen Riordan,
- Janett Fischer,
- Ulrich Spengler,
- Jacob Nattermann,
- Ahmed Wahid,
- Angela Rojas,
- Rose White,
- Mark W. Douglas,
- Duncan McLeod,
- Elizabeth Powell,
- Christopher Liddle,
- David van der Poorten,
- Jacob George,
- Mohammed Eslam,
- International Liver Disease Genetics Consortium
Affiliations
- Khaled Thabet
- Storr Liver Centre, Westmead Institute for Medical Research and Westmead Hospital, University of Sydney
- Anastasia Asimakopoulos
- Storr Liver Centre, Westmead Institute for Medical Research and Westmead Hospital, University of Sydney
- Maryam Shojaei
- Centre for Immunology and Allergy Research, Westmead Institute for Medical Research
- Manuel Romero-Gomez
- Unit for The Clinical Management of Digestive Diseases and CIBERehd, Hospital Universitario de Valme
- Alessandra Mangia
- Division of Hepatology, Ospedale Casa Sollievo della Sofferenza, IRCCS
- William L. Irving
- NIHR Biomedical Research Unit in Gastroenterology and the Liver, University of Nottingham
- Thomas Berg
- Section of Hepatology, Clinic for Gastroenterology and Rheumatology, University Clinic Leipzig
- Gregory J. Dore
- Kirby Institute, The University of New South Wales
- Henning Grønbæk
- Department of Hepatology and Gastroenterology, Aarhus University Hospital
- David Sheridan
- Institute of Translational and Stratified Medicine, Plymouth University
- Maria Lorena Abate
- Division of Gastroenterology and Hepatology, Department of Medical Science, University of Turin
- Elisabetta Bugianesi
- Division of Gastroenterology and Hepatology, Department of Medical Science, University of Turin
- Martin Weltman
- Department of Gastroenterology and Hepatology, Nepean Hospital
- Lindsay Mollison
- Department of Gastroenterology and Hepatology, Fremantle Hospital
- Wendy Cheng
- Department of Gastroenterology and Hepatology, Royal Perth Hospital
- Stephen Riordan
- Gastrointestinal and Liver Unit, Prince of Wales Hospital and University of New South Wales
- Janett Fischer
- Section of Hepatology, Clinic for Gastroenterology and Rheumatology, University Clinic Leipzig
- Ulrich Spengler
- Department of Internal Medicine I, University of Bonn
- Jacob Nattermann
- Department of Internal Medicine I, University of Bonn
- Ahmed Wahid
- Department of Biochemistry, Faculty of Pharmacy, Minia University
- Angela Rojas
- Unit for The Clinical Management of Digestive Diseases and CIBERehd, Hospital Universitario de Valme
- Rose White
- Storr Liver Centre, Westmead Institute for Medical Research and Westmead Hospital, University of Sydney
- Mark W. Douglas
- Storr Liver Centre, Westmead Institute for Medical Research and Westmead Hospital, University of Sydney
- Duncan McLeod
- Department of Anatomical Pathology, Institute of Clinical Pathology and Medical Research (ICPMR), Westmead Hospital
- Elizabeth Powell
- Princess Alexandra Hospital, School of Medicine, The University of Queensland
- Christopher Liddle
- Storr Liver Centre, Westmead Institute for Medical Research and Westmead Hospital, University of Sydney
- David van der Poorten
- Storr Liver Centre, Westmead Institute for Medical Research and Westmead Hospital, University of Sydney
- Jacob George
- Storr Liver Centre, Westmead Institute for Medical Research and Westmead Hospital, University of Sydney
- Mohammed Eslam
- Storr Liver Centre, Westmead Institute for Medical Research and Westmead Hospital, University of Sydney
- International Liver Disease Genetics Consortium
- DOI
- https://doi.org/10.1038/ncomms12757
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 8
Abstract
Chronic Hepatitis C infection is associated with a broad spectrum of liver pathologies, ranging from inflammation to fibrosis and liver cancer. Here Thabet et al. identified a polymorphism in the gene MBOAT7 that is associated with increased hepatic inflammation and higher risk of fibrosis development and progression.
