mBio
(Feb 2021)
Salmonella enterica Serovar Typhimurium Exploits Cycling through Epithelial Cells To Colonize Human and Murine Enteroids
Petra Geiser,
Maria Letizia Di Martino,
Pilar Samperio Ventayol,
Jens Eriksson,
Eduardo Sima,
Anas Kh. Al-Saffar,
David Ahl,
Mia Phillipson,
Dominic-Luc Webb,
Magnus Sundbom,
Per M. Hellström,
Mikael E. Sellin
Affiliations
Petra Geiser
ORCiD Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
Maria Letizia Di Martino
ORCiD Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
Pilar Samperio Ventayol
ORCiD Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
Jens Eriksson
ORCiD Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
Eduardo Sima
ORCiD Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
Anas Kh. Al-Saffar
ORCiD Department of Medical Sciences, Gastroenterology and Hepatology Unit, Uppsala University, Uppsala, Sweden
David Ahl
ORCiD Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
Mia Phillipson
ORCiD Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
Dominic-Luc Webb
ORCiD Department of Medical Sciences, Gastroenterology and Hepatology Unit, Uppsala University, Uppsala, Sweden
Magnus Sundbom
ORCiD Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
Per M. Hellström
ORCiD Department of Medical Sciences, Gastroenterology and Hepatology Unit, Uppsala University, Uppsala, Sweden
Mikael E. Sellin
ORCiD Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
DOI
https://doi.org/10.1128/mBio.02684-20
Journal volume & issue
Vol. 12,
no. 1
Abstract
Read online
Pathogenic gut bacteria are common causes of intestinal disease. Enteroids—cultured three-dimensional replicas of the mammalian gut—offer an emerging model system to study disease mechanisms under conditions that recapitulate key features of the intestinal tract.
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