Endocrinological implications of the obstructive sleep apnea-hypopnea syndrome (OSAHS)

Abstract

Since obstructive sleep apnea-hypopnea syndrome (OSAHS) is a multisystemic disease, it also affects the endocrine system. Normal production of hormones can be influenced by the presence of intermittent hypoxia, inflammation, and oxidative stress; for example, subjects with obesity and OSAHS have much higher leptin levels than obese subjects without OSAHS. This article discusses the relationship between sleep apnea and obesity, metabolic syndrome (MS), diabetes mellitus type 2 (DM2), neuroendocrine disorders and osteoporosis.

Keywords

• Síndromes de la apnea del sueño
• Obesidad
• Diabetes mellitus
• Osteoporosis.