Modelling traumatic brain injury and posttraumatic epilepsy in rodents

Rhys D. Brady; Pablo M. Casillas-Espinosa; Denes V. Agoston; Edward H. Bertram; Alaa Kamnaksh; Bridgette D. Semple; Sandy R. Shultz

Neurobiology of Disease (Mar 2019)

Modelling traumatic brain injury and posttraumatic epilepsy in rodents

Rhys D. Brady,
Pablo M. Casillas-Espinosa,
Denes V. Agoston,
Edward H. Bertram,
Alaa Kamnaksh,
Bridgette D. Semple,
Sandy R. Shultz

Affiliations

Rhys D. Brady: Departments of Neuroscience and Medicine, Central Clinical School, Monash University, VIC 3004, Australia; Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, VIC 3052, Australia; Corresponding authors at: Central Clinical School, Monash University, 6th Floor, The Alfred Centre, 99 Commercial Road, Melbourne, Victoria 3004, Australia.
Pablo M. Casillas-Espinosa: Departments of Neuroscience and Medicine, Central Clinical School, Monash University, VIC 3004, Australia; Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, VIC 3052, Australia; Corresponding authors at: Central Clinical School, Monash University, 6th Floor, The Alfred Centre, 99 Commercial Road, Melbourne, Victoria 3004, Australia.
Denes V. Agoston: Anatomy, Physiology & Genetics, Uniformed Services University, Bethesda, MD 20814, USA
Edward H. Bertram: Department of Neurology, University of Virginia, P.O. Box 800394, Charlottesville, VA 22908-0394, USA
Alaa Kamnaksh: Anatomy, Physiology & Genetics, Uniformed Services University, Bethesda, MD 20814, USA
Bridgette D. Semple: Departments of Neuroscience and Medicine, Central Clinical School, Monash University, VIC 3004, Australia; Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, VIC 3052, Australia
Sandy R. Shultz: Departments of Neuroscience and Medicine, Central Clinical School, Monash University, VIC 3004, Australia; Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, VIC 3052, Australia

Journal volume & issue: Vol. 123
pp. 8 – 19

Abstract

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Posttraumatic epilepsy (PTE) is one of the most debilitating and understudied consequences of traumatic brain injury (TBI). It is challenging to study the effects, underlying pathophysiology, biomarkers, and treatment of TBI and PTE purely in human patients for a number of reasons. Rodent models can complement human PTE studies as they allow for the rigorous investigation into the causal relationship between TBI and PTE, the pathophysiological mechanisms of PTE, the validation and implementation of PTE biomarkers, and the assessment of PTE treatments, in a tightly controlled, time- and cost-efficient manner in experimental subjects known to be experiencing epileptogenic processes. This article will review several common rodent models of TBI and/or PTE, including their use in previous studies and discuss their relative strengths, limitations, and avenues for future research to advance our understanding and treatment of PTE.

Published in Neurobiology of Disease

ISSN: 0969-9961 (Print); 1095-953X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neurobiology-of-disease

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Abstract

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