Misleading hepatitis B testing in the setting of intravenous immunoglobulin [v1; ref status: indexed, http://f1000r.es/25r]
Christelle M Ilboudo,
Erin M Guest,
Angela M Ferguson,
Uttam Garg,
Mary Anne Jackson
Affiliations
Christelle M Ilboudo
Children’s Mercy Hospitals and Clinics, Division of Infectious Diseases and University of Missouri-Kansas City School of Medicine, Kansas City, MO, 64108, USA
Erin M Guest
Children’s Mercy Hospitals and Clinics, Department of Pediatrics, Division of Hematology Oncology and University of Missouri-Kansas City School of Medicine, Kansas City, MO, 64108, USA
Angela M Ferguson
Children’s Mercy Hospital and Clinics, Department of Pathology and Laboratory Medicine, Division of Laboratory Medicine and University of Missouri-Kansas City School of Medicine, Kansas City, MO, 64108, USA
Uttam Garg
Children’s Mercy Hospital and Clinics, Department of Pathology and Laboratory Medicine, Division of Laboratory Medicine and University of Missouri-Kansas City School of Medicine, Kansas City, MO, 64108, USA
Mary Anne Jackson
Children’s Mercy Hospitals and Clinics, Division of Infectious Diseases and University of Missouri-Kansas City School of Medicine, Kansas City, MO, 64108, USA
Intravenous immunoglobulin (IVIG) is commonly used for a wide range of diagnoses, by multiple pediatric subspecialists. We report two cases of hepatitis B screening results post IVIG infusion, where positive anti-Hepatitis B core antigen serology tests indicated possible occult hepatitis infection, leading to a delay in care. However, serial antibody testing showed results consistent with the passive transfer of antibodies.
