Nature Communications (Apr 2023)
Spatial probabilistic mapping of metabolite ensembles in mass spectrometry imaging
- Denis Abu Sammour,
- James L. Cairns,
- Tobias Boskamp,
- Christian Marsching,
- Tobias Kessler,
- Carina Ramallo Guevara,
- Verena Panitz,
- Ahmed Sadik,
- Jonas Cordes,
- Stefan Schmidt,
- Shad A. Mohammed,
- Miriam F. Rittel,
- Mirco Friedrich,
- Michael Platten,
- Ivo Wolf,
- Andreas von Deimling,
- Christiane A. Opitz,
- Wolfgang Wick,
- Carsten Hopf
Affiliations
- Denis Abu Sammour
- Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences
- James L. Cairns
- Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences
- Tobias Boskamp
- Bruker Daltonics GmbH & Co. KG
- Christian Marsching
- Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences
- Tobias Kessler
- Clinical Cooperation Unit Neurooncology, German Cancer Consortium, German Cancer Research Center
- Carina Ramallo Guevara
- Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences
- Verena Panitz
- DKTK Metabolic Crosstalk in Cancer, German Consortium of Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ)
- Ahmed Sadik
- DKTK Metabolic Crosstalk in Cancer, German Consortium of Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ)
- Jonas Cordes
- Faculty of Computer Science, Mannheim University of Applied Sciences
- Stefan Schmidt
- Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences
- Shad A. Mohammed
- Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences
- Miriam F. Rittel
- Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences
- Mirco Friedrich
- Mannheim Center for Translational Neuroscience (MCTN), Medical Faculty Mannheim, Heidelberg University
- Michael Platten
- Mannheim Center for Translational Neuroscience (MCTN), Medical Faculty Mannheim, Heidelberg University
- Ivo Wolf
- Faculty of Computer Science, Mannheim University of Applied Sciences
- Andreas von Deimling
- Department of Neuropathology, University Hospital Heidelberg
- Christiane A. Opitz
- DKTK Metabolic Crosstalk in Cancer, German Consortium of Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ)
- Wolfgang Wick
- Clinical Cooperation Unit Neurooncology, German Cancer Consortium, German Cancer Research Center
- Carsten Hopf
- Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences
- DOI
- https://doi.org/10.1038/s41467-023-37394-z
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 15
Abstract
Spatial visualization of metabolites in tissues via mass spectrometry imaging can be prone to user perception bias. Here, the authors report the computational framework moleculaR that introduces probabilistic data-dependent molecular mapping of nonrandom spatial patterns of metabolite signals.
