Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets

Zhen Miao; Michael S. Balzer; Ziyuan Ma; Hongbo Liu; Junnan Wu; Rojesh Shrestha; Tamas Aranyi; Amy Kwan; Ayano Kondo; Marco Pontoglio; Junhyong Kim; Mingyao Li; Klaus H. Kaestner; Katalin Susztak

doi:10.1038/s41467-021-22266-1

Nature Communications (Apr 2021)

Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets

Zhen Miao,
Michael S. Balzer,
Ziyuan Ma,
Hongbo Liu,
Junnan Wu,
Rojesh Shrestha,
Tamas Aranyi,
Amy Kwan,
Ayano Kondo,
Marco Pontoglio,
Junhyong Kim,
Mingyao Li,
Klaus H. Kaestner,
Katalin Susztak

Affiliations

Zhen Miao: Renal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine
Michael S. Balzer: Renal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine
Ziyuan Ma: Renal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine
Hongbo Liu: Renal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine
Junnan Wu: Renal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine
Rojesh Shrestha: Renal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine
Tamas Aranyi: Renal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine
Amy Kwan: Department of Genetics, University of Pennsylvania, Perelman School of Medicine
Ayano Kondo: Department of Genetics, University of Pennsylvania, Perelman School of Medicine
Marco Pontoglio: Epigenetics and Development Laboratory, Université de Paris Inserm U1151/CNRS UMR 8253, Institut Necker Enfants Malades
Junhyong Kim: Department of Biology, University of Pennsylvania
Mingyao Li: Department of Epidemiology and Biostatistics, University of Pennsylvania, Perelman School of Medicine
Klaus H. Kaestner: Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, Perelman School of Medicine
Katalin Susztak: Renal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine

DOI: https://doi.org/10.1038/s41467-021-22266-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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Epigenetic and transcriptional dynamics are critical for both tissue homeostasis and injury response in the kidney. Leveraging a single cell multiomics atlas of the developing mouse kidney, the authors reveal key events in chromatin regulation and gene expression dynamics during postnatal development.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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