Nature Communications (Sep 2021)

Synthetic essentiality between PTEN and core dependency factor PAX7 dictates rhabdomyosarcoma identity

  • Casey G. Langdon,
  • Katherine E. Gadek,
  • Matthew R. Garcia,
  • Myron K. Evans,
  • Kristin B. Reed,
  • Madeline Bush,
  • Jason A. Hanna,
  • Catherine J. Drummond,
  • Matthew C. Maguire,
  • Patrick J. Leavey,
  • David Finkelstein,
  • Hongjian Jin,
  • Patrick A. Schreiner,
  • Jerold E. Rehg,
  • Mark E. Hatley

DOI
https://doi.org/10.1038/s41467-021-25829-4
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 18

Abstract

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PTEN copy number loss is found in 25% of fusion-negative rhabdomyosarcomas (FN-RMS). Here, the authors use a Hedgehog-driven FN-RMS mouse model to show that PTEN loss drives the expression of core transcription factor PAX7 and its transcriptional axis, which determines FN-RMS tumour identity.