Einstein (São Paulo) (Mar 2010)

Autoimmune uveitis: study of treatment therapies

  • Alessandra Gonçalves Commodaro,
  • Luciana de Deus Vieira de Moraes,
  • Denise Vilarinho Tambourgi,
  • Rubens Belfort Jr.,
  • Osvaldo Augusto Sant’Anna,
  • Luiz Vicente Rizzo

DOI
https://doi.org/10.1590/s1679-45082010rb1416
Journal volume & issue
Vol. 8, no. 1
pp. 117 – 121

Abstract

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ABSTRACT Experimental autoimmune uveitis is an organ-specific T-cell mediated autoimmune disease characterized by inflammation and consequent destruction of the neural retina and adjacent tissues. Inflammation in experimental autoimmune uveitis may be induced in rodents by immunization with retinal antigens, such as interphotoreceptor retinoid-binding protein. We present a review of experimental studies that correlate primary immunobiological functions with this chronic disease and the possible use of molecules for the treatment of autoimmune uveitis.

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