KRAP tethers IP3 receptors to actin and licenses them to evoke cytosolic Ca2+ signals

Abstract

Calcium signals initiated by IP3 receptors in ER membranes regulate most cellular activities. Here, the authors show that KRas-induced actininteracting protein (KRAP) tethers a small subset of IP3 receptors to actin and licenses them to evoke cytosolic calcium signals.