Nature Communications (Sep 2019)

Emulating evolutionary processes to morph aureothin-type modular polyketide synthases and associated oxygenases

  • Huiyun Peng,
  • Keishi Ishida,
  • Yuki Sugimoto,
  • Holger Jenke-Kodama,
  • Christian Hertweck

DOI
https://doi.org/10.1038/s41467-019-11896-1
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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The wealth of complex polyketides is an essential source for drug discovery. Here, the authors report an evolution-guided rational morphing of modular polyketide synthases (PKSs) for aurothin and neoaurothin biosynthesis, and reveal engineering site suitable for diversifying PKS systems.