Nature Communications (Sep 2019)
Emulating evolutionary processes to morph aureothin-type modular polyketide synthases and associated oxygenases
Abstract
The wealth of complex polyketides is an essential source for drug discovery. Here, the authors report an evolution-guided rational morphing of modular polyketide synthases (PKSs) for aurothin and neoaurothin biosynthesis, and reveal engineering site suitable for diversifying PKS systems.