Acute frataxin knockdown in induced pluripotent stem cell-derived cardiomyocytes activates a type I interferon response

• M. Grazia Cotticelli,
• Shujuan Xia,
• Rachel Truitt,
• Nicolai M. Doliba,
• Andrea V. Rozo,
• John W. Tobias,
• Taehee Lee,
• Justin Chen,
• Jill S. Napierala,
• Marek Napierala,
• Wenli Yang,
• Robert B. Wilson

Affiliations

M. Grazia Cotticelli

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA

Shujuan Xia

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA

Rachel Truitt

Department of Medicine, Division of Translational Medicine and Human Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA

Nicolai M. Doliba

Institute of Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, PA 19104, USA

Andrea V. Rozo

Institute of Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, PA 19104, USA

John W. Tobias

Department of Genetics, Penn Genomics Analysis Core, University of Pennsylvania, Philadelphia, PA 19104, USA

Taehee Lee

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA

Justin Chen

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA

Jill S. Napierala

Department of Neurology, UT Southwestern Medical Center, Dallas, TX 75390, USA

Marek Napierala

Department of Neurology, UT Southwestern Medical Center, Dallas, TX 75390, USA

Wenli Yang

Department of Medicine, Division of Translational Medicine and Human Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA

Robert B. Wilson

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA