RhopH2 and RhopH3 export enables assembly of the RhopH complex on P. falciparum-infected erythrocyte membranes

Michał Pasternak; Julie M. J. Verhoef; Wilson Wong; Tony Triglia; Michael J. Mlodzianoski; Niall Geoghegan; Cindy Evelyn; Ahmad Z. Wardak; Kelly Rogers; Alan F. Cowman

doi:10.1038/s42003-022-03290-3

Communications Biology (Apr 2022)

RhopH2 and RhopH3 export enables assembly of the RhopH complex on P. falciparum-infected erythrocyte membranes

Michał Pasternak,
Julie M. J. Verhoef,
Wilson Wong,
Tony Triglia,
Michael J. Mlodzianoski,
Niall Geoghegan,
Cindy Evelyn,
Ahmad Z. Wardak,
Kelly Rogers,
Alan F. Cowman

Affiliations

Michał Pasternak: The Walter and Eliza Hall Institute of Medical Research, Parkville
Julie M. J. Verhoef: The Walter and Eliza Hall Institute of Medical Research, Parkville
Wilson Wong: The Walter and Eliza Hall Institute of Medical Research, Parkville
Tony Triglia: The Walter and Eliza Hall Institute of Medical Research, Parkville
Michael J. Mlodzianoski: The Walter and Eliza Hall Institute of Medical Research, Parkville
Niall Geoghegan: The Walter and Eliza Hall Institute of Medical Research, Parkville
Cindy Evelyn: The Walter and Eliza Hall Institute of Medical Research, Parkville
Ahmad Z. Wardak: The Walter and Eliza Hall Institute of Medical Research, Parkville
Kelly Rogers: The Walter and Eliza Hall Institute of Medical Research, Parkville
Alan F. Cowman: The Walter and Eliza Hall Institute of Medical Research, Parkville

DOI: https://doi.org/10.1038/s42003-022-03290-3
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 12

Abstract

Read online

While RhopH3 is necessary for host invasion by Plasmodium falciparum parasites, the complete RhopH complex involved in parasite nutrient uptake only incorporates into the host membrane after merozoite invasion.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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