Synthesis and Characterization of Tetracycline Loaded Methionine-Coated NiFe<sub>2</sub>O<sub>4</sub> Nanoparticles for Anticancer and Antibacterial Applications
Faten Eshrati Yeganeh,
Amir Eshrati Yeganeh,
Bahareh Farasati Far,
Afsoun Mansouri,
Belay Zeleke Sibuh,
Saravanan Krishnan,
Soumya Pandit,
Walaa F. Alsanie,
Vijay Kumar Thakur,
Piyush Kumar Gupta
Affiliations
Faten Eshrati Yeganeh
Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran 1477893855, Iran
Amir Eshrati Yeganeh
Department of Microbiology, Noor Dahesh Institute of Higher Education, Meymeh 45789427600, Iran
Bahareh Farasati Far
Department of Chemistry, Iran University of Science and Technology, Tehran 1684613114, Iran
Afsoun Mansouri
School of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran 1477893855, Iran
Belay Zeleke Sibuh
Department of Biotechnology, School of Engineering and Technology, Sharda University, Plot no. 32–34, Knowledge Park III, Greater Noida 201310, Uttar Pradesh, India
Saravanan Krishnan
Creative Carbon Labs Pvt. Ltd., Chennai 600113, Tamil Nadu, India
Soumya Pandit
Department of Life Sciences, School of Basic Sciences and Research, Sharda University, Plot no. 32–34, Knowledge Park III, Greater Noida 201310, Uttar Pradesh, India
Walaa F. Alsanie
Department of Clinical Laboratories Sciences, The Faculty of Applied Medical Sciences, Taif University, Taif 21944, Saudi Arabia
Vijay Kumar Thakur
Biorefining and Advanced Materials Research Centre, Scotland’s Rural College (SRUC), Kings Buildings, Edinburgh EH9 3JG, UK
Piyush Kumar Gupta
Department of Life Sciences, School of Basic Sciences and Research, Sharda University, Plot no. 32–34, Knowledge Park III, Greater Noida 201310, Uttar Pradesh, India
In the present study, nickel ferrite (NiFe2O4)-based smart magnetic nanoparticles were fabricated and coated with methionine. Physiochemical characterization of the obtained Met-NiFe2O4 nanoparticles revealed the presence of methionine coating over the nanoparticle surface. Drug release study indicated that Tet-Met-NiFe2O4 nanoparticles possess pH-responsive controlled drug release behavior for tetracycline (Tet). The drug loading content for Tet was found to be 0.27 mg/L of nanoparticles. In vitro cytotoxicity test showed that the Met-NiFe2O4 nanoparticles is biocompatible. Moreover, this magnetic nanostructured material shown strong anticancer property as these nanomaterials significantly reduced the viability of A375 cells when compared to free Tet solution. In addition, Tet-Met-NiFe2O4 nanoparticles also showed strong antibacterial activity against different bacterial pathogens.
