A lipid gating mechanism for the channel-forming O antigen ABC transporter

Christopher A. Caffalette; Robin A. Corey; Mark S. P. Sansom; Phillip J. Stansfeld; Jochen Zimmer

doi:10.1038/s41467-019-08646-8

Nature Communications (Feb 2019)

A lipid gating mechanism for the channel-forming O antigen ABC transporter

Christopher A. Caffalette,
Robin A. Corey,
Mark S. P. Sansom,
Phillip J. Stansfeld,
Jochen Zimmer

Affiliations

Christopher A. Caffalette: Molecular Physiology and Biological Physics, University of Virginia School of Medicine
Robin A. Corey: Department of Biochemistry, University of Oxford
Mark S. P. Sansom: Department of Biochemistry, University of Oxford
Phillip J. Stansfeld: Department of Biochemistry, University of Oxford
Jochen Zimmer: Molecular Physiology and Biological Physics, University of Virginia School of Medicine

DOI: https://doi.org/10.1038/s41467-019-08646-8
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

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Bacterial O antigen polysaccharides play a role in innate immune response evasion. Here, the authors uncover the ATP-bound structure of the Aquifex aeolicus WzmWzt O antigen ABC transporter, shedding light onto the mechanism of lipid-linked polysaccharide translocation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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