Nature Communications (Sep 2020)

A role for annexin A2 in scaffolding the peroxiredoxin 2–STAT3 redox relay complex

  • Deepti Talwar,
  • Joris Messens,
  • Tobias P. Dick

DOI
https://doi.org/10.1038/s41467-020-18324-9
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

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Peroxiredoxin 2 (Prx2) was previously shown to transfer H2O2-derived oxidative equivalents to STAT3, generating disulfide-linked dimers and tetramers. Here the authors show that the interaction between Prx2 and STAT3 at the plasma membrane is mediated by the membrane chaperone annexin A2; suggesting that the redox relay complex is part of a membrane signaling domain.