Drug Design, Development and Therapy (Nov 2020)
HIF-1α is a Potential Molecular Target for Herbal Medicine to Treat Diseases
Abstract
Ruo-Lan Li,1 Li-Ying He,1 Qing Zhang,1 Jia Liu,1 Feng Lu,1 Hu-Xin-Yue Duan,1 Lin-Hong Fan,1 Wei Peng,1 Yong-Liang Huang,2 Chun-Jie Wu1 1School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, People’s Republic of China; 2Pharmacy Department, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, People’s Republic of ChinaCorrespondence: Yong-Liang Huang; Chun-Jie Wu Tel +86-28-6180-1001Email [email protected]; [email protected]: HIF-1α is an important factor regulating oxygen balance in mammals, and its expression is closely related to various physiological and pathological conditions of the body. Because HIF-1α plays an important role in the occurrence and development of cancer and other diseases, it has become an enduring research hotspot. At the same time, natural medicines and traditional Chinese medicine compounds have amazing curative effects in various diseases related to HIF-1 subtype due to their unique pharmacological effects and more effective ingredients. Therefore, in this article, we first outline the structure of HIF-1α and the regulation related to its expression, then introduce various diseases closely related to HIF-1α, and finally focus on the regulation of natural medicines and compound Chinese medicines through various pathways. This will help us understand HIF-1α systematically, and use HIF-1α as a target to discover more natural medicines and traditional Chinese medicines that can treat related diseases.Keywords: HIF-1α, disease, natural medicine, traditional Chinese medicine
