Antibody-powered nucleic acid release using a DNA-based nanomachine

Simona Ranallo; Carl Prévost-Tremblay; Andrea Idili; Alexis Vallée-Bélisle; Francesco Ricci

doi:10.1038/ncomms15150

Nature Communications (May 2017)

Antibody-powered nucleic acid release using a DNA-based nanomachine

Simona Ranallo,
Carl Prévost-Tremblay,
Andrea Idili,
Alexis Vallée-Bélisle,
Francesco Ricci

Affiliations

Simona Ranallo: Department of Chemistry, University of Rome, Tor Vergata, Via della Ricerca Scientifica
Carl Prévost-Tremblay: Département de Chimie, Laboratory of Biosensors and Nanomachines, Départment de Biochimie et Médecine Moléculaire, Université de Montréal
Andrea Idili: Department of Chemistry, University of Rome, Tor Vergata, Via della Ricerca Scientifica
Alexis Vallée-Bélisle: Département de Chimie, Laboratory of Biosensors and Nanomachines, Départment de Biochimie et Médecine Moléculaire, Université de Montréal
Francesco Ricci: Department of Chemistry, University of Rome, Tor Vergata, Via della Ricerca Scientifica

DOI: https://doi.org/10.1038/ncomms15150
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 9

Abstract

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Responsive molecular machines can perform specific tasks triggered by environmental or chemical stimuli. Here, the authors show that antibodies can be used as inputs to modulate the binding of a molecular cargo to a designed DNA-based nanomachine, with potential applications in diagnostics and drug delivery.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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