Nature Communications (Jul 2020)
Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers
- Yan Dora Zhang,
- Amber N. Hurson,
- Haoyu Zhang,
- Parichoy Pal Choudhury,
- Douglas F. Easton,
- Roger L. Milne,
- Jacques Simard,
- Per Hall,
- Kyriaki Michailidou,
- Joe Dennis,
- Marjanka K. Schmidt,
- Jenny Chang-Claude,
- Puya Gharahkhani,
- David Whiteman,
- Peter T. Campbell,
- Michael Hoffmeister,
- Mark Jenkins,
- Ulrike Peters,
- Li Hsu,
- Stephen B. Gruber,
- Graham Casey,
- Stephanie L. Schmit,
- Tracy A. O’Mara,
- Amanda B. Spurdle,
- Deborah J. Thompson,
- Ian Tomlinson,
- Immaculata De Vivo,
- Maria Teresa Landi,
- Matthew H. Law,
- Mark M. Iles,
- Florence Demenais,
- Rajiv Kumar,
- Stuart MacGregor,
- D. Timothy Bishop,
- Sarah V. Ward,
- Melissa L. Bondy,
- Richard Houlston,
- John K. Wiencke,
- Beatrice Melin,
- Jill Barnholtz-Sloan,
- Ben Kinnersley,
- Margaret R. Wrensch,
- Christopher I. Amos,
- Rayjean J. Hung,
- Paul Brennan,
- James McKay,
- Neil E. Caporaso,
- Sonja I. Berndt,
- Brenda M. Birmann,
- Nicola J. Camp,
- Peter Kraft,
- Nathaniel Rothman,
- Susan L. Slager,
- Andrew Berchuck,
- Paul D. P. Pharoah,
- Thomas A. Sellers,
- Simon A. Gayther,
- Celeste L. Pearce,
- Ellen L. Goode,
- Joellen M. Schildkraut,
- Kirsten B. Moysich,
- Laufey T. Amundadottir,
- Eric J. Jacobs,
- Alison P. Klein,
- Gloria M. Petersen,
- Harvey A. Risch,
- Rachel Z. Stolzenberg-Solomon,
- Brian M. Wolpin,
- Donghui Li,
- Rosalind A. Eeles,
- Christopher A. Haiman,
- Zsofia Kote-Jarai,
- Fredrick R. Schumacher,
- Ali Amin Al Olama,
- Mark P. Purdue,
- Ghislaine Scelo,
- Marlene D. Dalgaard,
- Mark H. Greene,
- Tom Grotmol,
- Peter A. Kanetsky,
- Katherine A. McGlynn,
- Katherine L. Nathanson,
- Clare Turnbull,
- Fredrik Wiklund,
- Breast Cancer Association Consortium (BCAC),
- Barrett’s and Esophageal Adenocarcinoma Consortium (BEACON),
- Colon Cancer Family Registry (CCFR),
- Transdisciplinary Studies of Genetic Variation in Colorectal Cancer (CORECT),
- Endometrial Cancer Association Consortium (ECAC),
- Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO),
- Melanoma Genetics Consortium (GenoMEL),
- Glioma International Case-Control Study (GICC),
- International Lung Cancer Consortium (ILCCO),
- Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Consortium,
- International Consortium of Investigators Working on Non-Hodgkin’s Lymphoma Epidemiologic Studies (InterLymph),
- Ovarian Cancer Association Consortium (OCAC),
- Oral Cancer GWAS,
- Pancreatic Cancer Case-Control Consortium (PanC4),
- Pancreatic Cancer Cohort Consortium (PanScan),
- Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL),
- Renal Cancer GWAS,
- Testicular Cancer Consortium (TECAC),
- Stephen J. Chanock,
- Nilanjan Chatterjee,
- Montserrat Garcia-Closas
Affiliations
- Yan Dora Zhang
- Department of Statistics and Actuarial Science, Faculty of Science, The University of Hong Kong
- Amber N. Hurson
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Haoyu Zhang
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Parichoy Pal Choudhury
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Douglas F. Easton
- Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Roger L. Milne
- Cancer Epidemiology Division, Cancer Council Victoria
- Jacques Simard
- Centre Hospitalier Universitaire de Québec–Université Laval Research Center
- Per Hall
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Kyriaki Michailidou
- Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Joe Dennis
- Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Marjanka K. Schmidt
- Division of Molecular Pathology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital
- Jenny Chang-Claude
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)
- Puya Gharahkhani
- Statistical Genetics, QIMR Berghofer Medical Research Institute
- David Whiteman
- Cancer Control, QIMR Berghofer Medical Research Institute
- Peter T. Campbell
- Behavioral and Epidemiology Research Group, American Cancer Society
- Michael Hoffmeister
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)
- Mark Jenkins
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne
- Ulrike Peters
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center
- Li Hsu
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center
- Stephen B. Gruber
- Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
- Graham Casey
- Department of Public Health Sciences, Center for Public Health Genomics, University of Virginia
- Stephanie L. Schmit
- Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institution
- Tracy A. O’Mara
- Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute
- Amanda B. Spurdle
- Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute
- Deborah J. Thompson
- Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Ian Tomlinson
- Institute of Cancer and Genomic Sciences, University of Birmingham
- Immaculata De Vivo
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Maria Teresa Landi
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Matthew H. Law
- Statistical Genetics, QIMR Berghofer Medical Research Institute
- Mark M. Iles
- Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds
- Florence Demenais
- Université de Paris, UMRS-1124, Institut National de la Santé et de la Recherche Médicale (INSERM)
- Rajiv Kumar
- Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ)
- Stuart MacGregor
- Statistical Genetics, QIMR Berghofer Medical Research Institute
- D. Timothy Bishop
- Division of Haematology and Immunology, Leeds Institute of Medical Research, University of Leeds
- Sarah V. Ward
- Centre for Genetic Origins of Health and Disease, School of Biomedical Sciences, The University of Western Australia
- Melissa L. Bondy
- Department of Medicine, Section of Epidemiology and Population Sciences, Baylor College of Medicine
- Richard Houlston
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- John K. Wiencke
- Department of Neurological Surgery, School of Medicine, University of California, San Francisco
- Beatrice Melin
- Department of Radiation Sciences Oncology, Umeå University
- Jill Barnholtz-Sloan
- Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine
- Ben Kinnersley
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Margaret R. Wrensch
- Department of Neurological Surgery, School of Medicine, University of California, San Francisco
- Christopher I. Amos
- Institute for Clinical and Translational Research, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine
- Rayjean J. Hung
- Lunenfeld-Tanenbuaum Research Institute, Sinai Health System
- Paul Brennan
- International Agency for Research on Cancer, World Health Organization
- James McKay
- International Agency for Research on Cancer, World Health Organization
- Neil E. Caporaso
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Sonja I. Berndt
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Brenda M. Birmann
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Nicola J. Camp
- Division of Hematology and Hematological Malignancies, University of Utah School of Medicine
- Peter Kraft
- Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health
- Nathaniel Rothman
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Susan L. Slager
- Division of Biomedical Statistics & Informatics, Department of Health Sciences Research, Mayo Clinic
- Andrew Berchuck
- Department of Gynecologic Oncology, Duke University Medical Center
- Paul D. P. Pharoah
- Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Thomas A. Sellers
- Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institution
- Simon A. Gayther
- Center for Bioinformatics and Functional Genomics and the Cedars Sinai Genomics Core, Cedars-Sinai Medical Center
- Celeste L. Pearce
- Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
- Ellen L. Goode
- Division of Epidemiology, Department of Health Science Research, Mayo Clinic
- Joellen M. Schildkraut
- Rollins School of Public Health, Emory University
- Kirsten B. Moysich
- Division of Cancer Prevention and Control, Roswell Park Cancer Institute
- Laufey T. Amundadottir
- Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Eric J. Jacobs
- Behavioral and Epidemiology Research Group, American Cancer Society
- Alison P. Klein
- Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine
- Gloria M. Petersen
- Division of Epidemiology, Department of Health Science Research, Mayo Clinic
- Harvey A. Risch
- Chronic Disease Epidemiology, Yale School of Medicine
- Rachel Z. Stolzenberg-Solomon
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Brian M. Wolpin
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Donghui Li
- Division of Cancer Medicine, GI Medical Oncology Department, The University of Texas MD Anderson Cancer Center
- Rosalind A. Eeles
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Christopher A. Haiman
- Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
- Zsofia Kote-Jarai
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Fredrick R. Schumacher
- Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine
- Ali Amin Al Olama
- Strangeways Research Laboratory, Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Mark P. Purdue
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Ghislaine Scelo
- International Agency for Research on Cancer, World Health Organization
- Marlene D. Dalgaard
- Department of Growth and Reproduction, Copenhagen University Hospital (Rigshospitalet)
- Mark H. Greene
- Clinical Genetics Branch, Division of Cancer Genetics and Epidemiology, National Cancer Institute
- Tom Grotmol
- Cancer Registry of Norway
- Peter A. Kanetsky
- Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institution
- Katherine A. McGlynn
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Katherine L. Nathanson
- Division of Translational Health and Human Genetics, Department of Medicine, University of Pennsylvania
- Clare Turnbull
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Fredrik Wiklund
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Breast Cancer Association Consortium (BCAC)
- Barrett’s and Esophageal Adenocarcinoma Consortium (BEACON)
- Colon Cancer Family Registry (CCFR)
- Transdisciplinary Studies of Genetic Variation in Colorectal Cancer (CORECT)
- Endometrial Cancer Association Consortium (ECAC)
- Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO)
- Melanoma Genetics Consortium (GenoMEL)
- Glioma International Case-Control Study (GICC)
- International Lung Cancer Consortium (ILCCO)
- Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Consortium
- International Consortium of Investigators Working on Non-Hodgkin’s Lymphoma Epidemiologic Studies (InterLymph)
- Ovarian Cancer Association Consortium (OCAC)
- Oral Cancer GWAS
- Pancreatic Cancer Case-Control Consortium (PanC4)
- Pancreatic Cancer Cohort Consortium (PanScan)
- Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL)
- Renal Cancer GWAS
- Testicular Cancer Consortium (TECAC)
- Stephen J. Chanock
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Nilanjan Chatterjee
- Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University
- Montserrat Garcia-Closas
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- DOI
- https://doi.org/10.1038/s41467-020-16483-3
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
In cancer many gene variants may contribute to disease etiology, but the impact of a given gene variant may have varied effect size. Here, the authors analyse summary statistics of genome-wide association studies from fourteen cancers, and show the utility of polygenic risk scores may vary depending on cancer type.
