Current Status and Future Therapeutic Options for Fecal Microbiota Transplantation
Sergii Tkach,
Andrii Dorofeyev,
Iurii Kuzenko,
Nadiya Boyko,
Tetyana Falalyeyeva,
Luigi Boccuto,
Emidio Scarpellini,
Nazarii Kobyliak,
Ludovico Abenavoli
Affiliations
Sergii Tkach
Ukrainian Research and Practical Centre of Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of the Ministry of Health of Ukraine, 01021 Kyiv, Ukraine
Andrii Dorofeyev
Shupyk National Medical Academy of Postgraduate Education, 04112 Kyiv, Ukraine
Iurii Kuzenko
Ukrainian Research and Practical Centre of Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of the Ministry of Health of Ukraine, 01021 Kyiv, Ukraine
Nadiya Boyko
RDE Center of Molecular Microbiology and Mucosal Immunology, Uzhhorod National University, 88000 Uzhhorod, Ukraine
Tetyana Falalyeyeva
Educational-Scientific Center, Institute of Biology and Medicine, Taras Shevchenko National University of Kyiv, 01601 Kyiv, Ukraine
Luigi Boccuto
School of Nursing, Healthcare Genetics Program, Clemson University, Clemson, SC 29646, USA
Emidio Scarpellini
Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing (ChroMetA), Catholic University of Leuven, 3000 Leuven, Belgium
Nazarii Kobyliak
Department of Histopathology, Medical Laboratory CSD, 03022 Kyiv, Ukraine
Ludovico Abenavoli
Department of Health Sciences, University “Magna Graecia”, Viale Europa-Germaneto, 88100 Catanzaro, Italy
The intestinal microbiota plays an important role in maintaining human health, and its alteration is now associated with the development of various gastrointestinal (ulcerative colitis, irritable bowel syndrome, constipation, etc.) and extraintestinal diseases, such as cancer, metabolic syndrome, neuropsychiatric diseases. In this context, it is not surprising that gut microbiota modification methods may constitute a therapy whose potential has not yet been fully investigated. In this regard, the most interesting method is thought to be fecal microbiota transplantation, which consists of the simultaneous replacement of the intestinal microbiota of a sick recipient with fecal material from a healthy donor. This review summarizes the most interesting findings on the application of fecal microbiota transplantation in gastrointestinal and extraintestinal pathologies.
