Artificial local magnetic field inhomogeneity enhances T2 relaxivity

Zijian Zhou; Rui Tian; Zhenyu Wang; Zhen Yang; Yijing Liu; Gang Liu; Ruifang Wang; Jinhao Gao; Jibin Song; Liming Nie; Xiaoyuan Chen

doi:10.1038/ncomms15468

Nature Communications (May 2017)

Artificial local magnetic field inhomogeneity enhances T2 relaxivity

Zijian Zhou,
Rui Tian,
Zhenyu Wang,
Zhen Yang,
Yijing Liu,
Gang Liu,
Ruifang Wang,
Jinhao Gao,
Jibin Song,
Liming Nie,
Xiaoyuan Chen

Affiliations

Zijian Zhou: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University
Rui Tian: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University
Zhenyu Wang: Department of Electronic Science and Fujian Key Laboratory of Plasma and Magnetic Resonance, Xiamen University
Zhen Yang: Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
Yijing Liu: Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
Gang Liu: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University
Ruifang Wang: Department of Electronic Science and Fujian Key Laboratory of Plasma and Magnetic Resonance, Xiamen University
Jinhao Gao: and Department of Chemical Biology, State Key Laboratory of Physical Chemistry of Solid Surfaces, The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University
Jibin Song: Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
Liming Nie: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University
Xiaoyuan Chen: Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health

DOI: https://doi.org/10.1038/ncomms15468
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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The signal detected in magnetic resonance imaging comes from the relaxation of proton nuclear magnetization. Here, Zhouet al. introduce magnetic field inhomogeneity as a parameter to design iron oxide nanoparticle clusters to enhance the relaxation rate of nearby protons, thereby increasing image contrast.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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