A child with perinatal HIV infection and long-term sustained virological control following antiretroviral treatment cessation

Avy Violari; Mark F. Cotton; Louise Kuhn; Diana B. Schramm; Maria Paximadis; Shayne Loubser; Sharon Shalekoff; Bianca Da Costa Dias; Kennedy Otwombe; Afaaf Liberty; James McIntyre; Abdel Babiker; Diana Gibb; Caroline T. Tiemessen

doi:10.1038/s41467-019-08311-0

Nature Communications (Jan 2019)

A child with perinatal HIV infection and long-term sustained virological control following antiretroviral treatment cessation

Avy Violari,
Mark F. Cotton,
Louise Kuhn,
Diana B. Schramm,
Maria Paximadis,
Shayne Loubser,
Sharon Shalekoff,
Bianca Da Costa Dias,
Kennedy Otwombe,
Afaaf Liberty,
James McIntyre,
Abdel Babiker,
Diana Gibb,
Caroline T. Tiemessen

Affiliations

Avy Violari: Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand
Mark F. Cotton: Family Clinical Research Unit, Department of Paediatrics and Child Health, Stellenbosch University
Louise Kuhn: Gertrude H. Sergievsky Center, College of Physicians and Surgeons; and Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center
Diana B. Schramm: Centre for HIV and STIs, National Institute for Communicable Diseases (NICD), of the National Health Laboratory Service (NHLS)
Maria Paximadis: Centre for HIV and STIs, National Institute for Communicable Diseases (NICD), of the National Health Laboratory Service (NHLS)
Shayne Loubser: Centre for HIV and STIs, National Institute for Communicable Diseases (NICD), of the National Health Laboratory Service (NHLS)
Sharon Shalekoff: Centre for HIV and STIs, National Institute for Communicable Diseases (NICD), of the National Health Laboratory Service (NHLS)
Bianca Da Costa Dias: Centre for HIV and STIs, National Institute for Communicable Diseases (NICD), of the National Health Laboratory Service (NHLS)
Kennedy Otwombe: Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand
Afaaf Liberty: Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand
James McIntyre: Anova Health Institute
Abdel Babiker: Medical Research Council, Clinical Trials Unit, University College London
Diana Gibb: Medical Research Council, Clinical Trials Unit, University College London
Caroline T. Tiemessen: Centre for HIV and STIs, National Institute for Communicable Diseases (NICD), of the National Health Laboratory Service (NHLS)

DOI: https://doi.org/10.1038/s41467-019-08311-0
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

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Some perinatally HIV infected children who have received early antiretroviral therapy (ART) show long-term sustained virological control after ART cessation. Here the authors describe a case who, at age 9.5 years, shows normal CD4:CD8 T cell ratios and has no detectable levels of replication-competent virus.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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