The gut mycobiome of healthy mice is shaped by the environment and correlates with metabolic outcomes in response to diet

Tahliyah S. Mims; Qusai Al Abdallah; Justin D. Stewart; Sydney P. Watts; Catrina T. White; Thomas V. Rousselle; Ankush Gosain; Amandeep Bajwa; Joan C. Han; Kent A. Willis; Joseph F. Pierre

doi:10.1038/s42003-021-01820-z

Communications Biology (Mar 2021)

The gut mycobiome of healthy mice is shaped by the environment and correlates with metabolic outcomes in response to diet

Tahliyah S. Mims,
Qusai Al Abdallah,
Justin D. Stewart,
Sydney P. Watts,
Catrina T. White,
Thomas V. Rousselle,
Ankush Gosain,
Amandeep Bajwa,
Joan C. Han,
Kent A. Willis,
Joseph F. Pierre

Affiliations

Tahliyah S. Mims: Department of Pediatrics, College of Medicine, The University of Tennessee Health Science Center
Qusai Al Abdallah: Department of Pediatrics, College of Medicine, The University of Tennessee Health Science Center
Justin D. Stewart: Department of Geography and the Environment, Villanova University
Sydney P. Watts: Department of Pediatrics, College of Medicine, The University of Tennessee Health Science Center
Catrina T. White: Department of Pediatrics, College of Medicine, The University of Tennessee Health Science Center
Thomas V. Rousselle: Department of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, College of Medicine, The University of Tennessee Health Science Center
Ankush Gosain: Division of Pediatric Surgery, Department of Surgery, College of Medicine, The University of Tennessee Health Science Center
Amandeep Bajwa: Department of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, College of Medicine, The University of Tennessee Health Science Center
Joan C. Han: Department of Pediatrics, College of Medicine, The University of Tennessee Health Science Center
Kent A. Willis: Department of Pediatrics, College of Medicine, The University of Tennessee Health Science Center
Joseph F. Pierre: Department of Pediatrics, College of Medicine, The University of Tennessee Health Science Center

DOI: https://doi.org/10.1038/s42003-021-01820-z
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 11

Abstract

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Tahliyah S. Mims et al. investigate the influence of the gut mycobiome abundance and composition on host metabolism. Using mice from four different commercial suppliers they find that the gut mycobiome is shaped by diet, and that abundance and composition correlate with key metabolic features. In particular they find that Thermomyces and Saccharomyces species most strongly associate with weight gain.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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