Histamine mediates the pro-inflammatory effect of latex of Calotropis procera in rats

Abstract

Introduction: Calotropis procera is known to produce contact dermatitis and the latex of this plant produces intense inflammation when injected locally. However, the precise mode of its pro-inflammatory effect is not known. In present study we have pharmacologically characterized the inflammation induced by latex of C. procera in a rat paw edema model and determined the role of histamine in latex-induced inflammation.

Keywords

• Calotropis procera
• Carrageenan
• Histamine
• Inflammation
• Anti-inflammatory drugs.