Effect of Functionally-Graded Calcium Titanate Film, Prepared by Metal-Organic Chemical Vapor Deposition, on Titanium Implant

Applied Sciences. 2019;9(1):172 DOI 10.3390/app9010172

 

Journal Homepage

Journal Title: Applied Sciences

ISSN: 2076-3417 (Print)

Publisher: MDPI AG

LCC Subject Category: Technology: Engineering (General). Civil engineering (General) | Science: Biology (General) | Science: Physics | Science: Chemistry

Country of publisher: Switzerland

Language of fulltext: English

Full-text formats available: PDF, HTML

 

AUTHORS

Naru Shiraishi (Division of Advanced Prosthetic Dentistry, Tohoku University Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-machi Aoba-ku, Sendai 980-8575, Japan)
Risa Ishiko-Uzuka (Division of Preventive Dentistry, Tohoku University Graduate School of Dentistry, Tohoku University, 4–1 Seiryo-machi Aoba-ku, Sendai 980-8575, Japan)
Kenta Takahashi (Division of Advanced Prosthetic Dentistry, Tohoku University Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-machi Aoba-ku, Sendai 980-8575, Japan)
Toru Ogawa (Division of Advanced Prosthetic Dentistry, Tohoku University Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-machi Aoba-ku, Sendai 980-8575, Japan)
Takahisa Anada (Institute for Materials Chemistry and Engineering, Kyushu University, CE41 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan)
Osamu Suzuki (Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry, Tohoku University, 4–1 Seiryo-machi Aoba-ku, Sendai 980-8575, Japan)
Takashi Goto (Division of Multi-Functional Materials, Institute for Materials Research, Tohoku University, 2–2–1 Katahira Aoba-ku, Sendai 980-8577, Japan)
Keiichi Sasaki (Division of Advanced Prosthetic Dentistry, Tohoku University Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-machi Aoba-ku, Sendai 980-8575, Japan)

EDITORIAL INFORMATION

Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 11 weeks

 

Abstract | Full Text

Calcium Titanate (CaTiO3) has been introduced as an attractive biomaterial for the enhancement of calcium phosphate deposition in vivo and in vitro. We hypothesized that CaTiO3 directly coated on titanium (Ti) by metal-organic chemical vapor deposition (MOCVD) could be a suitable candidate for biocompatible coatings for medical devices, particularly dental implants. To prove this hypothesis, surface characterization, cell culture, and animal study were completed in this study. The result of this study showed that CTO 800, a CaTiO3 film prepared by heating at 800 °C, had a high hydrophilic surface. Mouse bone marrow stromal ST-2 cells cultured on substrates and CTO 800 exhibited cell differentiation, represented by alkaline phosphatase activity, compared with cells cultured on non-coated Ti and CTO 700 (a CaTiO3 film prepared by heating at 700 °C). The push-in test value of CTO 800, a parameter that indicates the degree of osseointegration, was significantly higher than that of Ti. Calcium titanate coated on Ti by MOCVD has the potential to accelerate the process of osseointegration; thus, our results support the use of CaTiO3 coating for biocompatible biomaterial for medical applications, particularly dental implants.