Mediators of Inflammation (Jan 2009)

Serologic Investigations in Children with Inflammatory Bowel Disease and Food Allergy

  • Urszula Grzybowska-Chlebowczyk,
  • Halina Woś,
  • Aleksander L. Sieroń,
  • Sabina Więcek,
  • Aleksandra Auguściak-Duma,
  • Halina Koryciak-Komarska,
  • Joanna Kasznia-Kocot

DOI
https://doi.org/10.1155/2009/512695
Journal volume & issue
Vol. 2009

Abstract

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The aim of the study was the evaluation of frequency and titre of IgA ASCA and IgG ASCA and p-ANCA, c-ANCA in children with IBD and occurrence of ASCA antibodies in relation to coexistence of FA. Patients and methods. The study comprised 95 children at the ages of 2 to 18 years. The diagnosis of IBD was established on the basis of Porto criteria. Tests of blood serum were performed in all children: IgA and IgG ASCA, p-ANCA, c-ANCA using ELISA method. Results. IgE-dependent FA was found in 32.5% children with UC and in 21% with CD. We did not observe any relation between the occurrence of FA and the frequency and ASCA titre. p-ANCA were significantly more frequent in the group of children with UC. The occurrence of ASCA antibodies was observed in 73.7% of children with CD, 17.5% with UC and almost 30% with allergic colitis. Conclusions. Patients with CD and the presence of ASCA revealed a significantly more frequent localization of lesions within the small bowel and a tendency towards older age. We observed a connection between the occurrence of antibodies and the examined mutations of gene NOD2/CARD15.