ASSESSMENT OF 10-YEAR PROBABILITY OF OSTEOPOROTIC FRACTURES WITH THE RUSSIAN MODEL OF FRAX® IN A POPULATION-BASED SAMPLE 5 REGIONS OF RUSSIA

Abstract

Osteoporosis is a significant health problem due to high frequency of occurrence of fractures at a low traumatic impact. Densitometric examination does not allow to fully identify individuals with an increased risk of osteoporotic fractures, because bone mineral density is one of the components of the fracture cause in osteoporosis. Among the alternative methods of predicting the risk of fractures the algorithm FRAX® has become widely used in the world, which can be used to calculate 10-year probability of major osteoporotic fracture based on clinical risk factors that showed an independent effect on BMD and/ or bone strength. A survey in 5 regions of Russia showed that 31% of women and 4% of men had values of FRAX® above the threshold of therapeutic intervention and as a result, needed the indication of antiosteoporotic therapy. The greatest need for treatment and preventive measures as determined using the algorithm FRAX® was detected in women in the Siberian, Uralian and Central region and in men – in the North-Western and Uralian Federal districts.

Keywords

• osteoporosis
• epidemiology
• diagnosis of osteoporosis
• frax®
• absolute fracture risk
• intervention threshold