Nature Communications (Oct 2019)

Cellular sequestrases maintain basal Hsp70 capacity ensuring balanced proteostasis

  • Chi-ting Ho,
  • Tomas Grousl,
  • Oren Shatz,
  • Areeb Jawed,
  • Carmen Ruger-Herreros,
  • Marije Semmelink,
  • Regina Zahn,
  • Karsten Richter,
  • Bernd Bukau,
  • Axel Mogk

DOI
https://doi.org/10.1038/s41467-019-12868-1
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

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The sequestration of misfolded proteins into large assemblies by sequestrases is now considered as the third pillar in protein quality control besides chaperones and proteases. Here the authors characterise the functions of the sequestrases Hsp42 and Btn2 in the proteostasis network of S. cerevisiae and find that they protect cells from too exhaustive depletion of the Hsp70 system.