Frontiers in Microbiology (Feb 2024)
Bioactive polyketides and meroterpenoids from the mangrove-derived fungus Talaromyces flavus TGGP35
- Jin Cai,
- Jin Cai,
- Xueming Zhou,
- Xueming Zhou,
- Bin Wang,
- Bin Wang,
- Xuelong Zhang,
- Xuelong Zhang,
- Mengyao Luo,
- Mengyao Luo,
- Longtao Huang,
- Longtao Huang,
- Ruoxi Wang,
- Ruoxi Wang,
- Yonghao Chen,
- Yonghao Chen,
- Xiaoyang Li,
- Xiaoyang Li,
- Youping Luo,
- Youping Luo,
- Guangying Chen,
- Guangying Chen,
- Fei Cao,
- Guolei Huang,
- Guolei Huang,
- Caijuan Zheng,
- Caijuan Zheng
Affiliations
- Jin Cai
- Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China
- Jin Cai
- Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, China
- Xueming Zhou
- Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China
- Xueming Zhou
- Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, China
- Bin Wang
- Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China
- Bin Wang
- Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, China
- Xuelong Zhang
- Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China
- Xuelong Zhang
- Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, China
- Mengyao Luo
- Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China
- Mengyao Luo
- Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, China
- Longtao Huang
- Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China
- Longtao Huang
- Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, China
- Ruoxi Wang
- Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China
- Ruoxi Wang
- Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, China
- Yonghao Chen
- Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China
- Yonghao Chen
- Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, China
- Xiaoyang Li
- Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China
- Xiaoyang Li
- Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, China
- Youping Luo
- Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China
- Youping Luo
- Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, China
- Guangying Chen
- Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China
- Guangying Chen
- Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, China
- Fei Cao
- Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnostics of Education Ministry of China, College of Pharmaceutical Sciences, Hebei University, Baoding, China
- Guolei Huang
- Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China
- Guolei Huang
- Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, China
- Caijuan Zheng
- Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China
- Caijuan Zheng
- Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, China
- DOI
- https://doi.org/10.3389/fmicb.2024.1342843
- Journal volume & issue
-
Vol. 15
Abstract
Six new polyketides, which includes three new lactones (talarotones A–C) (1–3), one new polyketide (talarotide A) (4), two new polyenes (talaroyenes A, B) (5, 6), together with one new meroterpenoid (talaropenoid A) (7) and 13 known compounds (8–20) were isolated from the mangrove-derived fungus Talaromyces flavus TGGP35. The structure and configuration of the compounds 1–7 were elucidated from the data obtained from HR-ESI-MS, IR, 1D/2D NMR spectroscopy, Mo2 (OAc)4-induced electronic circular dichroism (ECD), CD spectroscopy, and modified Mosher's method. Compounds 5 and 20 displayed antioxidant activity with IC50 values of 0.40 and 1.36 mM, respectively. Compounds 3, 6, 11, 16, and 17 displayed cytotoxic activity against human cancer cells Hela, A549, and had IC50 values ranging from 28.89 to 62.23 μM. Compounds 7, 10–12, and 14–18 exhibited moderate or potent anti-insect activity against newly hatched larvae of Helicoverpa armigera Hubner, with IC50 values in the range 50–200 μg/mL. Compound 18 showed antibacterial activity against Ralstonia solanacearum with the MIC value of 50 μg/mL.
Keywords
