Laron syndrome: An experience of treatment of two cases

Abstract

Laron syndrome or growth hormone insensitivity is a rare disease presenting with severe postnatal growth failure. Clinically, in most circumstances, it is indistinguishable from growth hormone deficiency. Differentiating between the two conditions is important because the treatment modalities are different, expensive, and prolonged. Here, we share our experience with two cases of severe short stature who were initially diagnosed with growth hormone deficiency and both were treated with recombinant human growth hormone. However, eventually they were diagnosed with growth hormone insensitivity or Laron syndrome and initiated on recombinant human insulin like growth factor-1 (rhIGF-1) therapy.

Keywords

• Growth hormone deficiency
• Growth hormone insensitivity
• Laron syndrome
• Short stature
• Recombinant IGF1