Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu

Abstract

Hou et al. discover that regulatory T-cells secrete soluble fibrinogen-like protein 2 that induces endometrial macrophages to polarize towards a pro-repair phenotype through the SHP2-ERK1/2-STAT3 signaling pathway. These data provide insights into the immunology of endometriosis.