Identification of Hypoxia-Related Molecular Classification and Associated Gene Signature in Oral Squamous Cell Carcinoma

Chen Li; Xin Chen; Xiaolin Ren; Xiaolin Ren; Jia-lin Chen; Hao Chen; Jing-jia Yu; Qiu-chi Ran; Shuang Kang; Xi-meng Chen; Zhen-jin Zhao

doi:10.3389/fonc.2021.709865

Frontiers in Oncology (Nov 2021)

Identification of Hypoxia-Related Molecular Classification and Associated Gene Signature in Oral Squamous Cell Carcinoma

Chen Li,
Xin Chen,
Xiaolin Ren,
Xiaolin Ren,
Jia-lin Chen,
Hao Chen,
Jing-jia Yu,
Qiu-chi Ran,
Shuang Kang,
Xi-meng Chen,
Zhen-jin Zhao

Affiliations

Chen Li: Department of Orthodontics, The First Clinic of Stomatological Hospital of China Medical University, Shenyang, China
Xin Chen: Department of Neurosurgery, The First Hospital of China Medical University, Shenyang, China
Xiaolin Ren: Department of Neurosurgery, The First Hospital of China Medical University, Shenyang, China
Xiaolin Ren: Department of Neurosurgery, Shenyang Red Cross Hospital, Shenyang, China
Jia-lin Chen: Department of Orthodontics, The First Clinic of Stomatological Hospital of China Medical University, Shenyang, China
Hao Chen: Department of Orthodontics, The First Clinic of Stomatological Hospital of China Medical University, Shenyang, China
Jing-jia Yu: Department of Orthodontics, The First Clinic of Stomatological Hospital of China Medical University, Shenyang, China
Qiu-chi Ran: Department of Orthodontics, The First Clinic of Stomatological Hospital of China Medical University, Shenyang, China
Shuang Kang: Department of Orthodontics, The First Clinic of Stomatological Hospital of China Medical University, Shenyang, China
Xi-meng Chen: Department of Orthodontics, The First Clinic of Stomatological Hospital of China Medical University, Shenyang, China
Zhen-jin Zhao: Department of Orthodontics, The First Clinic of Stomatological Hospital of China Medical University, Shenyang, China

DOI: https://doi.org/10.3389/fonc.2021.709865
Journal volume & issue: Vol. 11

Abstract

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The high heterogeneity of oral squamous cell carcinoma (OSCC) is the main obstacle for individualized treatment. Recognizing the characteristics of different subtypes and investigating the promising strategies for each subclass are of great significance in precise treatment. In this study, we systematically evaluated hypoxia-mediated patterns together with immune characteristics of 309 OSCC patients in the TCGA training set and 97 patients in the GSE41613 testing set. We further identified two different hypoxia subtypes with distinct immune microenvironment traits and provided treatment programs for the two subclasses. In order to assess hypoxia level individually, we finally constructed a hypoxia-related risk score, which could predict the clinical outcome and immunotherapy response of OSCC patients. In summary, the recognition of different hypoxia patterns and the establishment of hypoxia-related risk score might enhance our understanding of the tumor microenvironment of OSCC and provide more personalized treatment strategies in the future.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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