Targeting lipid metabolism overcomes BTK inhibitor resistance in diffuse large B-cell lymphoma

Zhuojun Liu; Chenyue Wu; Zhaohua Yao; Yuxuan Wang; Zhe Yu; Jian Yu

Medicine in Novel Technology and Devices (Jun 2024)

Targeting lipid metabolism overcomes BTK inhibitor resistance in diffuse large B-cell lymphoma

Zhuojun Liu,
Chenyue Wu,
Zhaohua Yao,
Yuxuan Wang,
Zhe Yu,
Jian Yu

Affiliations

Zhuojun Liu: School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China; Key Laboratory of Biomechanics and Mechanobiology, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China
Chenyue Wu: School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China; Key Laboratory of Biomechanics and Mechanobiology, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China
Zhaohua Yao: School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China; Key Laboratory of Biomechanics and Mechanobiology, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China
Yuxuan Wang: School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China; Key Laboratory of Biomechanics and Mechanobiology, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China
Zhe Yu: Shandong Provincial Third Hospital, Shandong, 250031, China; Corresponding author. Shandong Provincial Third Hospital, Shandong, 250031, China.
Jian Yu: School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China; Key Laboratory of Biomechanics and Mechanobiology, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China; Corresponding author. School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China.

Journal volume & issue: Vol. 22
p. 100295

Abstract

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Exploring novel therapeutic targets of Diffuse large B cell lymphoma (DLBCL) to overcome its resistance to Bruton's Tyrosine Kinase (BTK) inhibitors is a key topic. Lipid metabolism, crucial in the resistance landscape of various cancers, may unlock new aspects of BTK inhibitor resistance in DLBCL. Despite the known importance of lipid metabolism in oncological resistance patterns, its intricate role in DLBCL and its resistance to BTK inhibitor therapies remains largely uncharted. This review will explore the complex relationship between lipid metabolism and BTK inhibitor resistance, giving new insights for improving the effectiveness of BTK inhibitors and developing innovative combination treatment methods for DLBCL. This review holds the potential for guiding future research directions, optimizing existing therapeutic processes, and inspiring the development of innovative combinatorial therapeutic strategies that improve outcomes in patients with DLBCL.

Published in Medicine in Novel Technology and Devices

ISSN: 2590-0935 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General): Medical technology
Website: https://www.journals.elsevier.com/medicine-in-novel-technology-and-devices

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